BONUS 301: Recurrent Implantation Failure & Loss

March 19, 2021

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Today’s bonus episode guest is Dr. Allison Rodgers. She is board certified in both Obstetrics and Gynecology and Reproductive Endocrinology and Infertility and has been practicing medicine since 2004. Dr. Rodgers currently practices at the Fertility Centers of Illinois. Her personal experiences with both secondary infertility and pregnancy loss have given her a unique insight into reproductive medicine in order to help you beat infertility.

Episode Sponsor:

Infertility Coaching with Heather Huhman

Dr. Rodgers begins by answering six listener questions. The full questions are read on the air, but here are brief summaries:

  • Sarah, 35, has been trying for a second child for over three years after the quick and spontaneous conception of her first child. After two failed IUIs and a chemical pregnancy, she is devastated. She asks if she should keep trying even though there are no answers and where she should go from here.
  • Aishat, 37, lives in Nigeria. She’s had three hysteroscopies due to Asherman’s syndrome but hasn’t gotten her period back. She asks if there are any other procedures she should try.
  • Claire, 36, has secondary infertility. It took her six months to conceive her son, who is 2-½ now. She had two back-to-back miscarriages with no subsequent D & C procedures. She asks if her Prozac could have caused the miscarriages.
  • Julia, 34, is worried about her ovarian reserve. She only has two frozen embryos and is ready to transfer, but she’s afraid she might close the door on a second child. She asks if she should move forward now, even though a failure would mean another retrieval cycle for her.
  • Renee, 34, had her recent IVF failure because all four of her embryos arrested. All were mature and fertilized with ICSI. Her RE blamed egg quality, but the embryologist called it “textbook DNA fragmentation.” She asks about lab procedures and the specifics of egg quality.
  • Su, 40, lives in Denmark. She’s had four failed FETs from two different donor embryos. She is currently on Day 8 following her fifth FET, which was preceded by an ERA. She asks for advice since her RE isn’t sure what to do next.

Dr. Rodgers and Heather continue the episode by discussing preimplantation, the implantation process, and the role beta-3 integrins and progesterone resistance play in recurrent implantation failure and miscarriages.:

  • Can you tell us about the facts concerning the structure of the endometrium before implantation?
  • Is there an ideal or minimum thickness for the endometrium to accept an embryo?
  • Is it possible for the endometrium to break down and no longer be a good environment for the embryo?
  • Tell us more about the window of uterine receptivity and what the testing options are.
  • What are the mediators when it comes to implantation?
  • Tell us about the different steps in the process of implantation.
  • What are microRNAs?
  • What are the things that disrupt implantation?

Have a question you want Dr. Rodgers to answer next time she’s on? Click here.

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