Today’s bonus episode guest is Dr. Carol Curchoe, the founder of ART Compass, a senior clinical embryologist at a fertility clinic and a board-certified technical supervisor in embryology.
Dr. Curchoe and Heather discuss what we know in 2020 about mosaicism:
- I’d like to start by hearing a little bit about you. Tell us about your academic background and training.
- Why did you choose a career in reproductive physiology?
- Take us through your career.
MOSAICISM IN 2020
- What is a mosaic embryo?
- Like any “first draft,” embryos prioritize replication — or growth — over accuracy. Tell us about the early mechanisms of cell replication.
- What causes mosaicism?
- Can the IVF lab influence mosaicism?
- Tell us about the embryo biopsy process and false negatives and positives.
- What is “next-generation DNA sequencing” and how is it done?
- What chromosomal errors do doctors recommend patients avoid, and why?
- ASRM recently published a guideline about mosaicism based on a review of past studies. What does it mean to review past studies, and what are the limitations of this method of research?
- What are the 3 main risk categories associated with transferring a mosaic embryo?
- Can a mosaic embryo result in a healthy pregnancy? Which mosaic embryos are safe to transfer?
- What is recommended in terms of genetic counseling?
- Is there anything else you’d like to add about the guideline?
- Is there anything else you’d like to add about mosaicism?
- What words of hope would you offer to infertility warriors who have been told one or more of their embryos are mosaic?