BONUS 281: Mosaicism: 2020 Update

October 16, 2020

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Today’s bonus episode guest is Dr. Carol Curchoe, the founder of ART Compass, a senior clinical embryologist at a fertility clinic and a board-certified technical supervisor in embryology.

Episode Sponsor:

Infertility Coaching with Heather Huhman

Dr. Curchoe and Heather discuss what we know in 2020 about mosaicism:

INTRODUCTION

  • I’d like to start by hearing a little bit about you. Tell us about your academic background and training.
  • Why did you choose a career in reproductive physiology?
  • Take us through your career.

MOSAICISM IN 2020

  • What is a mosaic embryo?
  • Like any “first draft,” embryos prioritize replication — or growth — over accuracy. Tell us about the early mechanisms of cell replication.
  • What causes mosaicism?
  • Can the IVF lab influence mosaicism?
  • Tell us about the embryo biopsy process and false negatives and positives.
  • What is “next-generation DNA sequencing” and how is it done?
  • What chromosomal errors do doctors recommend patients avoid, and why?
  • ASRM recently published a guideline about mosaicism based on a review of past studies. What does it mean to review past studies, and what are the limitations of this method of research?
    • What are the 3 main risk categories associated with transferring a mosaic embryo?
    • Can a mosaic embryo result in a healthy pregnancy? Which mosaic embryos are safe to transfer?
    • What is recommended in terms of genetic counseling?
    • Is there anything else you’d like to add about the guideline?
  • Is there anything else you’d like to add about mosaicism?

WRAPPING UP

  • What words of hope would you offer to infertility warriors who have been told one or more of their embryos are mosaic?

References:

Thanks for listening!

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